Structural analysis of peptides with nuclear magnetic resonance (NMR) spectroscopy generally relies on knowledge of the primary sequence to enable assignment of the resonances prior to determination of the three-dimensional structure.Resonance assignment without knowledge of the sequence is complicated by redundancy in amino acid type, making compl
ER stress affects processing of MHC class I-associated peptides
Abstract Background Viral infection and neoplastic transformation trigger endoplasmic reticulum (ER) stress.Thus, a large proportion of the cells that must be recognized by the immune system are stressed cells.Cells respond to ER stress by launching the unfolded protein response (UPR).The UPR regulates the two key processes that control major histo
A convergence research perspective on graduate education for sustainable urban systems science
Abstract Sustainable urban systems (SUS) science is a new science integrating work across established and emerging disciplines, using diverse methods, and addressing issues at local, regional, national, and global scales.Advancing SUS requires the next generation of scholars and practitioners to excel at synthesis CLOVE across disciplines and posse
Development of functional bioflavor based on Indonesian indigenous microbial fermentation products
Abstract Bioflavor and fermented foods in Indonesian cuisine were interesting for studying the relationship between fermentation products, microbial aspects, functional implications and biotechnological applications.The methodology employed in the literature review, including the sources used and inclusion criteria, demonstrates a meticulous approa
First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer
Abstract Background Lung cancer is a malignant carcinoma which has the highest morbidity and mortality in Chinese Meat population.Gefitinib, a tyrosine kinase (TK) inhibitor of epidermal growth factor receptor (EGFR), displays anti-tumor activity.The present data regarding first-line treatment with single agent gefitinib against non-small-cell lung